MolNFT v1 · #89879 · protein

Crystal structure of a tyrosine 3-MONOOXYGENASE/TRYPTOPHAN 5- monooxygenase activation protein, gamma polypeptide (ywhag) from homo sapiens at 2.25 a resolution

4E2E · 14-3-3 protein gamma: “Crystal structure of a tyrosine 3-MONOOXYGENASE/TRYPTOPHAN 5- monooxygenase activation protein, gamma…”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #89879 on GenesisL1: 3D structure…

PDB: 4E2E
Type: protein
Length: 235 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 14-3-3 protein gamma
UniProt: P61981
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 84% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	14-3-3 protein gamma	protein	235	84% helix, 0% strand	P61981

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	203	0.50	0.76	31	empty

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

4E2E · Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation… · the same entry in another collection · chain A against A, TM-score 1.00
P61981 · AlphaFold monomer V2.0 prediction for 14-3-3 protein gamma (P61981) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61981
Elsewhere: RCSB PDB 4E2E · PDBe 4E2E · UniProt P61981

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