MolNFT v1 · #8984 · protein
The antigenic identity of PEPTIDE(SLASH)MHC complexes: a comparison of the conformation of five peptides presented by HLA-A2
1HHI · Class I histocompatibility antigen (HLA-A*0201) (alpha…: “The antigenic identity of PEPTIDE(SLASH)MHC complexes: a comparison of the conformation of five peptides…”. X-ray diffraction, 9 pockets (best druggability 0.71). MolNFT v1…
- PDB
- 1HHI
- Type
- protein
- Length
- 768 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Class I histocompatibility antigen (HLA-A*0201) (alpha chain); Beta 2-microglobulin…
- UniProt
- P01892, P61769, P03485
- Pockets
- 9 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Class I histocompatibility antigen (HLA-A*0201) (alpha chain) | protein | 275 | 27% helix, 39% strand | P01892 |
| B, E | Beta 2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C, F | Influenza a matrix protein M1 (residues 58-66) | protein | 9 | 0% helix, 0% strand | P03485 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 553 | 0.71 | 0.80 | 48 | empty |
| 2 | 628 | 0.69 | 0.77 | 58 | empty |
| 3 | 165 | 0.51 | 0.78 | 24 | empty |
| 4 | 126 | 0.44 | 0.77 | 18 | empty |
| 5 | 124 | 0.42 | 0.76 | 23 | empty |
Interfaces
6 interfaces between chains.
- D–E · 1420 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1408 Ų buried · 25 hydrogen bonds · protein-protein
- D–F · 838 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 835 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 288 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1HHI · The antigenic identity of PEPTIDE(SLASH)MHC complexes: a comparison of the conformation… · the same entry in another collection · chain F against F, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01892
- Every structure of UniProt P61769
- Every structure of UniProt P03485
- Elsewhere: RCSB PDB 1HHI · PDBe 1HHI · UniProt P01892 · UniProt P61769 · UniProt P03485
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.