MolNFT v1 · #89701 · protein
Crystal structure of the human TRPV4 ankyrin repeat domain
4DX2 · Transient receptor potential cation channel subfamily V…: “Crystal structure of the human TRPV4 ankyrin repeat domain”. X-ray diffraction, 2 ligands (ATP, BGC), 8 pockets (best druggability 0.77). MolNFT v1 #89701 on GenesisL1: 3D…
- PDB
- 4DX2
- Type
- protein
- Length
- 492 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 4
- UniProt
- Q9HBA0
- Ligands
- ATP, BGC
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 4 | protein | 247 | 52% helix, 2% strand | Q9HBA0 |
| B | Transient receptor potential cation channel subfamily V member 4 | protein | 245 | 51% helix, 2% strand | Q9HBA0 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- BGC · beta-D-glucopyranose · sugar · chains A
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 699 | 0.77 | 0.82 | 68 | empty |
| 2 | 84 | 0.42 | 0.78 | 16 | empty |
| 3 | 129 | 0.42 | 0.76 | 24 | empty |
| 4 | 105 | 0.41 | 0.77 | 15 | empty |
| 5 | 80 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 703 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 4DX2 · Crystal structure of the human TRPV4 ankyrin repeat domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HBA0 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HBA0
- Elsewhere: RCSB PDB 4DX2 · PDBe 4DX2 · UniProt Q9HBA0
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