MolNFT v1 · #8942 · protein
Alpha-lactalbumin
1HFZ: “Alpha-lactalbumin”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.31). MolNFT v1 #8942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1HFZ
- Type
- protein
- Length
- 491 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-lactalbumin
- EC
- 2.4.1.22
- UniProt
- P00711
- Ligands
- CA
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-lactalbumin (EC 2.4.1.22) | protein | 123 | 45% helix, 11% strand | P00711 |
| B, C | Alpha-lactalbumin (EC 2.4.1.22) | protein | 122 | 45% helix, 10% strand | P00711 |
| D | Alpha-lactalbumin (EC 2.4.1.22) | protein | 124 | 44% helix, 10% strand | P00711 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.31 | 0.73 | 12 | empty |
Interfaces
2 interfaces between chains.
- B–D · 87 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 44 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00711
- Elsewhere: RCSB PDB 1HFZ · PDBe 1HFZ · UniProt P00711
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