MolNFT v1 · #89148 · protein
The wild-type src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)
4DGP · Tyrosine-protein phosphatase non-receptor type 11: “The wild-type src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT v1 #89148 on GenesisL1…
- PDB
- 4DGP
- Type
- protein
- Length
- 499 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 11
- EC
- 3.1.3.48
- UniProt
- Q06124
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) | protein | 499 | 31% helix, 25% strand | Q06124 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.66 | 0.79 | 40 | empty |
| 2 | 115 | 0.45 | 0.78 | 27 | empty |
| 3 | 125 | 0.40 | 0.75 | 27 | empty |
| 4 | 77 | 0.38 | 0.78 | 17 | empty |
| 5 | 75 | 0.36 | 0.77 | 17 | empty |
Compared structures
- 4DGP · The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 4DGP · PDBe 4DGP · UniProt Q06124
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