MolNFT v1 · #89143 · protein
Structure of a human enteropeptidase light chain variant
4DGJ · Enteropeptidase catalytic light chain: “Structure of a human enteropeptidase light chain variant”. X-ray diffraction, 11 pockets (best druggability 0.78). MolNFT v1 #89143 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4DGJ
- Type
- protein
- Length
- 938 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enteropeptidase catalytic light chain
- EC
- 3.4.21.9
- UniProt
- P98073
- Pockets
- 11 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Enteropeptidase catalytic light chain (EC 3.4.21.9) | protein | 235 | 9% helix, 38% strand | P98073 |
| C, D | Enteropeptidase catalytic light chain (EC 3.4.21.9) | protein | 234 | 9% helix, 39% strand | P98073 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1145 | 0.78 | 0.80 | 104 | empty |
| 2 | 158 | 0.50 | 0.78 | 28 | empty |
| 3 | 147 | 0.48 | 0.78 | 34 | empty |
| 4 | 134 | 0.45 | 0.77 | 31 | empty |
| 5 | 129 | 0.44 | 0.77 | 17 | empty |
Interfaces
5 interfaces between chains.
- B–C · 703 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 638 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 423 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 371 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 106 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P98073
- Elsewhere: RCSB PDB 4DGJ · PDBe 4DGJ · UniProt P98073
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