UniProt P98073
Enteropeptidase (P98073)
Enteropeptidase (UniProt P98073), EC 3.4.21.9: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P98073
- Protein
- Enteropeptidase
- EC
- 3.4.21.9
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 6 records with a druggable one
Structures
10 records of P98073 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DGJ | Structure of a human enteropeptidase light chain variant | x-ray diffraction | A, B, C, D | — | — |
| 4DGJ | Structure of a human enteropeptidase light chain variant | x-ray diffraction | A, B, C, D | — | — |
| 6ZOV | Enteropeptidase in complex with compound 6 | x-ray diffraction | A, B, C, D | GBS | 11 (best 0.78) |
| 6ZOV | Enteropeptidase in complex with compound 6 | x-ray diffraction | A, B, C, D | GBS | — |
| 7WQW | Structure of Active-EP | electron microscopy | A, B | NAG | 5 (best 0.70) |
| 7WQX | Structure of Inactive-EP | electron microscopy | A | NAG | 4 (best 0.67) |
| 7WQZ | Structure of Active-mutEP | electron microscopy | A, B | NAG | 4 (best 0.71) |
| 7WR7 | Structure of Inhibited-EP | electron microscopy | A, B | NAG, GBS | 5 (best 0.68) |
| 8H3U | Inhibitor-bound EP, polyA model | electron microscopy | A, B | — | 6 (best 0.70) |
| P98073 | AlphaFold monomer V2.0 prediction for enteropeptidase (P98073) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4DGJ chain D against the predicted model P98073: TM-score 0.99, RMSD 0.73 Å
- 4DGJ chain D against the predicted model P98073: TM-score 0.99, RMSD 0.73 Å
- 6ZOV chain A against the predicted model P98073: TM-score 0.99, RMSD 0.75 Å
- 6ZOV chain A against the predicted model P98073: TM-score 0.99, RMSD 0.75 Å
- 4DGJ chain C against the predicted model P98073: TM-score 0.99, RMSD 0.77 Å
- 4DGJ chain C against the predicted model P98073: TM-score 0.99, RMSD 0.77 Å
- 6ZOV chain C against the predicted model P98073: TM-score 0.99, RMSD 0.78 Å
- 6ZOV chain C against the predicted model P98073: TM-score 0.99, RMSD 0.78 Å
- 6ZOV chain B against the predicted model P98073: TM-score 0.98, RMSD 0.80 Å
- 6ZOV chain B against the predicted model P98073: TM-score 0.98, RMSD 0.80 Å
Elsewhere
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