MolNFT v1 · #88627 · protein

Crystal structure of human CSN4

4D0P · COP9 signalosome complex subunit 4: “Crystal structure of human CSN4”. X-ray diffraction, 2 ligands (NA, CL), 2 pockets (best druggability 0.39). MolNFT v1 #88627 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4D0P
Type: protein
Length: 371 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: COP9 signalosome complex subunit 4
UniProt: Q9BT78
Ligands: NA, CL
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	COP9 signalosome complex subunit 4	protein	371	71% helix, 4% strand	Q9BT78

Ligands and binding sites

NA · Sodium ion · metal · 2 copies · chains A
CL · Chloride ion · ion · 8 copies · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	102	0.39	0.76	20	empty
2	83	0.38	0.77	16	empty

Compared structures

4D0P · Crystal structure of human CSN4 · the same entry in another collection · chain A against A, TM-score 1.00
Q9BT78 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 4 (Q9BT78) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BT78
Elsewhere: RCSB PDB 4D0P · PDBe 4D0P · UniProt Q9BT78

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