MolNFT v1 · #88621 · protein
Structure of RAB14 in complex with rab-coupling protein (rcp)
4D0G · RAS-related protein rab-14: “Structure of RAB14 in complex with rab-coupling protein (rcp)”. X-ray diffraction, 2 ligands (GTP, MG), 2 pockets (best druggability 0.44). MolNFT v1 #88621 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4D0G
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-14; RAB11 family-interacting protein 1
- UniProt
- P61106, Q6WKZ4
- Ligands
- GTP, MG
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-14 | protein | 167 | 34% helix, 27% strand | P61106 |
| C | RAB11 family-interacting protein 1 | protein | 46 | 80% helix, 2% strand | Q6WKZ4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.44 | 0.78 | 26 | GTP, MG |
| 2 | 53 | 0.31 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–C · 617 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4D0G · Structure of Rab14 in complex with Rab-Coupling Protein (RCP) · the same entry in another collection · chain A against A, TM-score 1.00
- P61106 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-14 (P61106) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q6WKZ4 · AlphaFold monomer V2.0 prediction for RAB11 family-interacting protein 1 (Q6WKZ4) · a predicted model of the same protein · chain C against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61106
- Every structure of UniProt Q6WKZ4
- Elsewhere: RCSB PDB 4D0G · PDBe 4D0G · UniProt P61106 · UniProt Q6WKZ4
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