MolNFT v1 · #88123 · protein
Crystal structure of human soluble adenylyl cyclase (apo form)
4CLF · Adenylate cyclase type 10: “Crystal structure of human soluble adenylyl cyclase (apo form)”. X-ray diffraction, 6 pockets (best druggability 0.80). MolNFT v1 #88123 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CLF
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase type 10
- EC
- 4.6.1.1
- UniProt
- Q96PN6
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase type 10 (EC 4.6.1.1) | protein | 461 | 38% helix, 28% strand | Q96PN6 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.80 | 0.93 | 31 | empty |
| 2 | 272 | 0.74 | 0.87 | 45 | ACT |
| 3 | 205 | 0.67 | 0.85 | 30 | empty |
| 4 | 151 | 0.42 | 0.74 | 24 | empty |
| 5 | 61 | 0.38 | 0.79 | 16 | GOL |
Modifications
Observed in the structure: 1 modified (artifact).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PN6
- Elsewhere: RCSB PDB 4CLF · PDBe 4CLF · UniProt Q96PN6
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