MolNFT v1 · #87855 · protein
Structure of ZNRF3 ectodomain
4CDJ · E3 ubiquitin-protein ligase ZNRF3: “Structure of ZNRF3 ectodomain”. X-ray diffraction, 4 pockets (best druggability 0.52). MolNFT v1 #87855 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CDJ
- Type
- protein
- Length
- 307 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase ZNRF3
- EC
- 6.3.2.-
- UniProt
- Q5SSZ7
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 153 | 22% helix, 34% strand | Q5SSZ7 |
| B | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 154 | 21% helix, 34% strand | Q5SSZ7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.52 | 0.80 | 24 | empty |
| 2 | 86 | 0.46 | 0.81 | 17 | empty |
| 3 | 73 | 0.44 | 0.81 | 18 | empty |
| 4 | 64 | 0.33 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1134 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SSZ7
- Elsewhere: RCSB PDB 4CDJ · PDBe 4CDJ · UniProt Q5SSZ7
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