MolNFT v1 · #87854 · protein

Crystal structure of acrb-acrz complex

4CDI · Acriflavine resistance protein B: “Crystal structure of acrb-acrz complex”. X-ray diffraction, 12 pockets (best druggability 0.82). MolNFT v1 #87854 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CDI
Type: protein
Length: 1,078 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acriflavine resistance protein B; Predicted protein
UniProt: P31224, C4ZXT3
Pockets: 12 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acriflavine resistance protein B	protein	1032	54% helix, 17% strand	P31224
C	Predicted protein	protein	46	74% helix, 0% strand	C4ZXT3

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	942	0.82	0.83	129	empty
2	162	0.78	0.94	39	empty
3	204	0.66	0.85	28	empty
4	72	0.65	0.93	27	empty
5	275	0.65	0.81	35	empty

Interfaces

1 interface between chains.

A–C · 1361 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4CDI · Crystal structure of AcrB-AcrZ complex · the same entry in another collection · chain A against A, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Every structure of UniProt C4ZXT3
Elsewhere: RCSB PDB 4CDI · PDBe 4CDI · UniProt P31224 · UniProt C4ZXT3

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