Crystallographic structure of the human IGG1 alpha 2-6 sialilated Fc- fragment

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 43% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
• MAN · alpha-D-mannopyranose · sugar · 4 copies · chains A, B
• GAL · beta-D-galactopyranose · sugar · 3 copies · chains A, B
• BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B
• FUL · beta-L-fucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 1143 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

• 4CDH · Crystallographic structure of the Human Igg1 alpha 2-6 sialilated Fc-Fragment · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01857
• Elsewhere: RCSB PDB 4CDH · PDBe 4CDH · UniProt P01857