Structure of L1196M mutant human anaplastic lymphoma kinase in complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl) PHENYL)ETHOXY)PYRIDIN-3-yl)-4-methylthiazol-2-YL)PROPANE-1,2-diol

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Ligands and binding sites

• AWJ · (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4CD0 · Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UM73
• Elsewhere: RCSB PDB 4CD0 · PDBe 4CD0 · UniProt Q9UM73