MolNFT v1 · #87421 · protein

Mammalian translation elongation factor EEF1A2

4C0S · Elongation factor 1-alpha 2: “Mammalian translation elongation factor EEF1A2”. X-ray diffraction, 2 ligands (GDP, MG), 13 pockets (best druggability 0.74). MolNFT v1 #87421 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4C0S
Type: protein
Length: 893 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongation factor 1-alpha 2
UniProt: Q71V39
Ligands: GDP, MG
Pockets: 13 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Elongation factor 1-alpha 2	protein	451	22% helix, 31% strand	Q71V39
B	Elongation factor 1-alpha 2	protein	442	21% helix, 34% strand	Q71V39

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	834	0.74	0.78	87	empty
2	466	0.68	0.79	43	empty
3	153	0.61	0.84	26	empty
4	98	0.59	0.87	22	empty
5	164	0.58	0.82	27	empty

Interfaces

1 interface between chains.

A–B · 2548 Å² buried · 34 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (phosphorylation).

Compared structures

4C0S · Mammalian translation elongation factor eEF1A2 · the same entry in another collection · chain B against B, TM-score 1.00
Q71V39 · AlphaFold monomer V2.0 prediction for elongation factor 1-alpha 2 (Q71V39) · a predicted model of the same protein · chain B against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q71V39
Elsewhere: RCSB PDB 4C0S · PDBe 4C0S · UniProt Q71V39

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