MolNFT v1 · #87415 · protein
Crystal structure of the N terminal domain of wild type trif (tir-domain-containing adapter-inducing interferon-beta)
4C0M · Tir domain-containing adapter molecule 1: “Crystal structure of the N terminal domain of wild type trif (tir-domain-containing adapter-inducing…”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #87415 on GenesisL1…
- PDB
- 4C0M
- Type
- protein
- Length
- 563 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tir domain-containing adapter molecule 1
- UniProt
- Q8IUC6
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tir domain-containing adapter molecule 1 | protein | 140 | 64% helix, 0% strand | Q8IUC6 |
| B, C, D | Tir domain-containing adapter molecule 1 | protein | 141 | 64% helix, 0% strand | Q8IUC6 |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 954 | 0.74 | 0.78 | 81 | empty |
| 2 | 160 | 0.45 | 0.75 | 23 | empty |
| 3 | 141 | 0.44 | 0.76 | 22 | empty |
| 4 | 141 | 0.43 | 0.76 | 21 | empty |
| 5 | 132 | 0.42 | 0.75 | 22 | empty |
Interfaces
4 interfaces between chains.
- B–C · 363 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 187 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 156 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 20 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4C0M · Crystal Structure of the N terminal domain of wild type TRIF (TIR- domain-containing… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IUC6 · AlphaFold monomer V2.0 prediction for tir domain-containing adapter molecule 1 (Q8IUC6) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IUC6
- Elsewhere: RCSB PDB 4C0M · PDBe 4C0M · UniProt Q8IUC6
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