MolNFT v1 · #87411 · protein
Extended interface between PCF11P and CLP1P and structural basis for ATP loss in GLY135ARG point mutant
4C0H · MRNA cleavage and polyadenylation factor CLP1: “Extended interface between PCF11P and CLP1P and structural basis for ATP loss in GLY135ARG point mutant”. X-ray diffraction, 9 pockets (best druggability 0.76). MolNFT v1 #87411 on…
- PDB
- 4C0H
- Type
- protein
- Length
- 910 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA cleavage and polyadenylation factor CLP1; PCF11P
- UniProt
- Q08685, N1P6M1
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA cleavage and polyadenylation factor CLP1 | protein | 422 | 29% helix, 30% strand | Q08685 |
| B | MRNA cleavage and polyadenylation factor CLP1 | protein | 427 | 30% helix, 30% strand | Q08685 |
| C | PCF11P | protein | 28 | 29% helix, 4% strand | N1P6M1 |
| D | PCF11P | protein | 33 | 24% helix, 9% strand | N1P6M1 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.76 | 0.84 | 43 | empty |
| 2 | 141 | 0.65 | 0.87 | 28 | empty |
| 3 | 255 | 0.62 | 0.81 | 42 | empty |
| 4 | 156 | 0.54 | 0.81 | 22 | empty |
| 5 | 169 | 0.53 | 0.79 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–D · 2035 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 1885 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 955 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4C0H · Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q08685 · AlphaFold monomer V2.0 prediction for mRNA cleavage and polyadenylation factor CLP1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08685
- Every structure of UniProt N1P6M1
- Elsewhere: RCSB PDB 4C0H · PDBe 4C0H · UniProt Q08685 · UniProt N1P6M1
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