Research workbench
Extended interface between PCF11P and CLP1P and structural basis for ATP loss in GLY135ARG point mutant
Analyse Extended interface between PCF11P and CLP1P and structural basis for ATP loss… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C0H
- Type
- protein
- Length
- 910 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA cleavage and polyadenylation factor CLP1; PCF11P
- UniProt
- Q08685, N1P6M1
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA cleavage and polyadenylation factor CLP1 | protein | 422 | 29% helix, 30% strand | Q08685 |
| B | MRNA cleavage and polyadenylation factor CLP1 | protein | 427 | 30% helix, 30% strand | Q08685 |
| C | PCF11P | protein | 28 | 29% helix, 4% strand | N1P6M1 |
| D | PCF11P | protein | 33 | 24% helix, 9% strand | N1P6M1 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.76 | 0.84 | 43 | empty |
| 2 | 141 | 0.65 | 0.87 | 28 | empty |
| 3 | 255 | 0.62 | 0.81 | 42 | empty |
| 4 | 156 | 0.54 | 0.81 | 22 | empty |
| 5 | 169 | 0.53 | 0.79 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–D · 2035 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 1885 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 955 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4C0H · Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q08685 · AlphaFold monomer V2.0 prediction for mRNA cleavage and polyadenylation factor CLP1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08685
- Every structure of UniProt N1P6M1
- Elsewhere: RCSB PDB 4C0H · PDBe 4C0H · UniProt Q08685 · UniProt N1P6M1
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