MolNFT v1 · #87280 · protein
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)
4BW5 · Potassium channel subfamily K member 10: “Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)”. X-ray diffraction, 3 ligands (PC1, K, CD), 19 pockets (best druggability 0.74). MolNFT v1 #87280 on…
- PDB
- 4BW5
- Type
- protein
- Length
- 985 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel subfamily K member 10
- UniProt
- P57789
- Ligands
- PC1, K, CD
- Pockets
- 19 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium channel subfamily K member 10 | protein | 248 | 76% helix, 0% strand | P57789 |
| B | Potassium channel subfamily K member 10 | protein | 254 | 77% helix, 0% strand | P57789 |
| C | Potassium channel subfamily K member 10 | protein | 233 | 77% helix, 0% strand | P57789 |
| D | Potassium channel subfamily K member 10 | protein | 250 | 78% helix, 0% strand | P57789 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 2 copies · chains A, B
- K · Potassium ion · metal · 8 copies · chains A, B, C, D
- CD · Cadmium ion · metal · 2 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1079 | 0.74 | 0.77 | 89 | empty |
| 2 | 562 | 0.67 | 0.77 | 37 | empty |
| 3 | 549 | 0.66 | 0.77 | 35 | empty |
| 4 | 705 | 0.65 | 0.75 | 59 | empty |
| 5 | 100 | 0.64 | 0.88 | 19 | empty |
Interfaces
5 interfaces between chains.
- A–B · 5362 Ų buried · 40 hydrogen bonds · protein-protein
- C–D · 5225 Ų buried · 40 hydrogen bonds · protein-protein
- B–D · 250 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 23 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 15 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4BW5 · Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) · the same entry in another collection · chain D against D, TM-score 1.00
- P57789 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 10 (P57789) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57789
- Elsewhere: RCSB PDB 4BW5 · PDBe 4BW5 · UniProt P57789
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