MolNFT v1 · #8720 · protein
Active mutant (S215->C) of glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides
1H93 · Glucose 6-phosphate 1-dehydrogenase: “Active mutant (S215->C) of glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides”. X-ray diffraction, 1 ligand (CA), 5 pockets (best druggability 0.64). MolNFT v1 #8720 on GenesisL1…
- PDB
- 1H93
- Type
- protein
- Length
- 485 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose 6-phosphate 1-dehydrogenase
- EC
- 1.1.1.49
- UniProt
- P11411
- Ligands
- CA
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose 6-phosphate 1-dehydrogenase (EC 1.1.1.49) | protein | 485 | 40% helix, 20% strand | P11411 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 388 | 0.64 | 0.78 | 43 | empty |
| 2 | 112 | 0.40 | 0.76 | 19 | empty |
| 3 | 94 | 0.36 | 0.75 | 16 | empty |
| 4 | 50 | 0.28 | 0.75 | 13 | empty |
| 5 | 52 | 0.27 | 0.73 | 15 | empty |
Compared structures
- 1H93 · Active mutant (S215->C) of glucose 6-phosphate dehydrogenase from leuconostoc… · the same entry in another collection · chain A against A, TM-score 1.00
- P11411 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P11411) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11411
- Elsewhere: RCSB PDB 1H93 · PDBe 1H93 · UniProt P11411
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