MolNFT v1 · #87176 · protein
Crystal structure of the yeast ribosomal protein RPS3 in complex with its chaperone YAR1
4BSZ · 40S ribosomal protein S3: “Crystal structure of the yeast ribosomal protein RPS3 in complex with its chaperone YAR1”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #87176 on GenesisL1: 3D structure, binding sites…
- PDB
- 4BSZ
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 40S ribosomal protein S3; Ankyrin repeat-containing protein YAR1
- UniProt
- P05750, P46683
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 40S ribosomal protein S3 | protein | 187 | 38% helix, 30% strand | P05750 |
| B | Ankyrin repeat-containing protein YAR1 | protein | 150 | 62% helix, 1% strand | P46683 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.58 | 0.79 | 37 | empty |
| 2 | 65 | 0.30 | 0.74 | 12 | empty |
| 3 | 66 | 0.30 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1477 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 4BSZ · Crystal Structure of the Yeast Ribosomal Protein Rps3 in Complex with its Chaperone Yar1 · the same entry in another collection · chain A against A, TM-score 1.00
- P46683 · AlphaFold monomer V2.0 prediction for ankyrin repeat-containing protein YAR1 (P46683) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P05750 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S3 (P05750) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05750
- Every structure of UniProt P46683
- Elsewhere: RCSB PDB 4BSZ · PDBe 4BSZ · UniProt P05750 · UniProt P46683
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