MolNFT v1 · #86921 · protein
Crystal structure of full-length human suppressor of fused (sufu) mutant lacking a regulatory subdomain (crystal form I)
4BL9 · Maltose-binding periplasmic protein, suppressor of fused…: “Crystal structure of full-length human suppressor of fused (sufu) mutant lacking a regulatory subdomain…”. X-ray diffraction, 1 ligand (GLC), 20 pockets (best druggability…
- PDB
- 4BL9
- Type
- protein
- Length
- 2,899 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, suppressor of fused homolog
- UniProt
- P0AEX9, Q9UMX1
- Ligands
- GLC
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 722 | 37% helix, 24% strand | P0AEX9, Q9UMX1 |
| B | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 729 | 36% helix, 24% strand | P0AEX9, Q9UMX1 |
| C | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 724 | 37% helix, 23% strand | P0AEX9, Q9UMX1 |
| D | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 724 | 36% helix, 24% strand | P0AEX9, Q9UMX1 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 970 | 0.79 | 0.81 | 107 | GLC |
| 2 | 527 | 0.75 | 0.82 | 68 | empty |
| 3 | 392 | 0.74 | 0.84 | 45 | GLC |
| 4 | 729 | 0.73 | 0.79 | 68 | empty |
| 5 | 369 | 0.73 | 0.84 | 43 | GLC |
Interfaces
4 interfaces between chains.
- B–C · 1274 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 534 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 267 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 62 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4BL9 · Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UMX1 · AlphaFold monomer V2.0 prediction for suppressor of fused homolog (Q9UMX1) · a predicted model of the same protein · chain C against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt Q9UMX1
- Elsewhere: RCSB PDB 4BL9 · PDBe 4BL9 · UniProt P0AEX9 · UniProt Q9UMX1
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