MolNFT v1 · #86800 · protein + RNA
Crystal structure of tetramer of la crosse virus nucleoprotein in complex with ssrna
4BHH: “Crystal structure of tetramer of la crosse virus nucleoprotein in complex with ssrna”. X-ray diffraction, 10 pockets (best druggability 0.80). MolNFT v1 #86800 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4BHH
- Type
- protein + RNA
- Length
- 953 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein; Poly-uridine 45-mer
- UniProt
- P04873
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Nucleoprotein | protein | 231 | 56% helix, 4% strand | P04873 |
| D, Z | Nucleoprotein | protein | 223 | 58% helix, 4% strand | P04873 |
| F | Nucleoprotein | protein | 232 | 55% helix, 4% strand | P04873 |
| R | Poly-uridine 45-mer | rna | 44 | — | — |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 987 | 0.80 | 0.82 | 79 | empty |
| 2 | 953 | 0.79 | 0.81 | 85 | empty |
| 3 | 643 | 0.75 | 0.82 | 65 | empty |
| 4 | 675 | 0.73 | 0.80 | 73 | empty |
| 5 | 236 | 0.51 | 0.76 | 32 | empty |
Interfaces
9 interfaces between chains.
- F–R · 1517 Ų buried · 35 hydrogen bonds · protein-nucleic
- B–R · 1485 Ų buried · 33 hydrogen bonds · protein-nucleic
- D–R · 1374 Ų buried · 26 hydrogen bonds · protein-nucleic
- R–Z · 1339 Ų buried · 25 hydrogen bonds · protein-nucleic
- F–Z · 992 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4BHH · Crystal structure of tetramer of La Crosse virus nucleoprotein in complex with ssRNA · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04873
- Elsewhere: RCSB PDB 4BHH · PDBe 4BHH · UniProt P04873
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