Research workbench
Crystal structure of tetramer of la crosse virus nucleoprotein in complex with ssrna
Analyse Crystal structure of tetramer of la crosse virus nucleoprotein in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BHH
- Type
- protein + RNA
- Length
- 953 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein; Poly-uridine 45-mer
- UniProt
- P04873
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Nucleoprotein | protein | 231 | 56% helix, 4% strand | P04873 |
| D, Z | Nucleoprotein | protein | 223 | 58% helix, 4% strand | P04873 |
| F | Nucleoprotein | protein | 232 | 55% helix, 4% strand | P04873 |
| R | Poly-uridine 45-mer | rna | 44 | — | — |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 987 | 0.80 | 0.82 | 79 | empty |
| 2 | 953 | 0.79 | 0.81 | 85 | empty |
| 3 | 643 | 0.75 | 0.82 | 65 | empty |
| 4 | 675 | 0.73 | 0.80 | 73 | empty |
| 5 | 236 | 0.51 | 0.76 | 32 | empty |
Interfaces
9 interfaces between chains.
- F–R · 1517 Ų buried · 35 hydrogen bonds · protein-nucleic
- B–R · 1485 Ų buried · 33 hydrogen bonds · protein-nucleic
- D–R · 1374 Ų buried · 26 hydrogen bonds · protein-nucleic
- R–Z · 1339 Ų buried · 25 hydrogen bonds · protein-nucleic
- F–Z · 992 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4BHH · Crystal structure of tetramer of La Crosse virus nucleoprotein in complex with ssRNA · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04873
- Elsewhere: RCSB PDB 4BHH · PDBe 4BHH · UniProt P04873
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