MolNFT v1 · #86516 · protein
Complex of VAMP7 cytoplasmic domain with 2ND ankyrin repeat domain of varp
4B93 · Vesicle-associated membrane protein 7: “Complex of VAMP7 cytoplasmic domain with 2ND ankyrin repeat domain of varp”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #86516 on GenesisL1: 3D structure, binding sites…
- PDB
- 4B93
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vesicle-associated membrane protein 7; Ankyrin repeat domain-containing protein 27
- UniProt
- P70280, Q96NW4
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicle-associated membrane protein 7 | protein | 157 | 34% helix, 29% strand | P70280 |
| B | Ankyrin repeat domain-containing protein 27 | protein | 191 | 47% helix, 1% strand | Q96NW4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.44 | 0.83 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 679 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4B93 · Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp · the same entry in another collection · chain A against A, TM-score 1.00
- Q96NW4 · AlphaFold monomer V2.0 prediction for ankyrin repeat domain- containing protein 27… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P70280 · AlphaFold monomer V2.0 prediction for vesicle-associated membrane protein 7 (P70280) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70280
- Every structure of UniProt Q96NW4
- Elsewhere: RCSB PDB 4B93 · PDBe 4B93 · UniProt P70280 · UniProt Q96NW4
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