Research workbench
Complex of VAMP7 cytoplasmic domain with 2ND ankyrin repeat domain of varp
Analyse Complex of VAMP7 cytoplasmic domain with 2ND ankyrin repeat domain of varp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B93
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vesicle-associated membrane protein 7; Ankyrin repeat domain-containing protein 27
- UniProt
- P70280, Q96NW4
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicle-associated membrane protein 7 | protein | 157 | 34% helix, 29% strand | P70280 |
| B | Ankyrin repeat domain-containing protein 27 | protein | 191 | 47% helix, 1% strand | Q96NW4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.44 | 0.83 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 679 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4B93 · Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp · the same entry in another collection · chain A against A, TM-score 1.00
- Q96NW4 · AlphaFold monomer V2.0 prediction for ankyrin repeat domain- containing protein 27… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P70280 · AlphaFold monomer V2.0 prediction for vesicle-associated membrane protein 7 (P70280) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70280
- Every structure of UniProt Q96NW4
- Elsewhere: RCSB PDB 4B93 · PDBe 4B93 · UniProt P70280 · UniProt Q96NW4
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