MolNFT v1 · #86219 · protein

Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid 2-arachidonoylglycerol

4AZQ · Fatty acid-binding protein, epidermal: “Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid 2-arachidonoylglycerol”. X-ray diffraction, 2 ligands (G2A, CL), 1 pocket (best druggability 0.82).…

PDB: 4AZQ
Type: protein
Length: 136 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, epidermal
UniProt: Q05816
Ligands: G2A, CL
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, epidermal	protein	136	15% helix, 57% strand	Q05816

Ligands and binding sites

G2A · 2-hydroxy-1-(hydroxymethyl)ethyl icosanoate · ligand · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	375	0.82	0.90	38	G2A

Compared structures

4AZQ · Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid… · the same entry in another collection · chain A against A, TM-score 1.00
Q05816 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein 5 (Q05816) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05816
Elsewhere: RCSB PDB 4AZQ · PDBe 4AZQ · UniProt Q05816

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