MolNFT v1 · #86181 · protein

Structure of the GH47 processing alpha-1,2-mannosidase from caulobacter strain K31

4AYO · Mannosyl-oligosaccharide 1,2-alpha-mannosidase: “Structure of the GH47 processing alpha-1,2-mannosidase from caulobacter strain K31”. X-ray diffraction, 2 ligands (CA, NA), 3 pockets (best druggability 0.70). MolNFT v1 #86181 on…

PDB: 4AYO
Type: protein
Length: 434 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mannosyl-oligosaccharide 1,2-alpha-mannosidase
EC: 3.2.1.113
UniProt: B0SWV2
Ligands: CA, NA
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113)	protein	434	51% helix, 13% strand	B0SWV2

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A
NA · Sodium ion · metal · chains A
BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.70	0.98	19	empty
2	236	0.59	0.80	35	CA, BTB
3	98	0.44	0.79	20	CA

Compared structures

4AYO · Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0SWV2
Elsewhere: RCSB PDB 4AYO · PDBe 4AYO · UniProt B0SWV2

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