MolNFT v1 · #85986 · protein
Structure of the complex between the N-terminal dimerisation domain of SGT2 and the ubl domain of GET5
4ASW · Small glutamine-rich tetratricopeptide repeat-containing…: “Structure of the complex between the N-terminal dimerisation domain of SGT2 and the ubl domain of GET5”. Solution nmr, 2 pockets (best druggability 0.38). MolNFT v1 #85986…
- PDB
- 4ASW
- Type
- protein
- Length
- 239 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small glutamine-rich tetratricopeptide repeat-containing protein 2; Ubiquitin-like…
- UniProt
- Q12118, Q12285
- Pockets
- 2 · best druggability 0.38
Structure
solution nmr · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Small glutamine-rich tetratricopeptide repeat-containing protein 2 | protein | 79 | 65% helix, 0% strand | Q12118 |
| C | Ubiquitin-like protein MDY2 | protein | 81 | 20% helix, 36% strand | Q12285 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.38 | 0.77 | 15 | empty |
| 2 | 75 | 0.37 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1618 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 447 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 432 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 4ASW · Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL… · the same entry in another collection · chain A against A, TM-score 1.00
- Q12285 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein MDY2 (Q12285) · a predicted model of the same protein · chain C against A, TM-score 0.93
- Q12118 · AlphaFold monomer V2.0 prediction for small glutamine-rich tetratricopeptide… · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12118
- Every structure of UniProt Q12285
- Elsewhere: RCSB PDB 4ASW · PDBe 4ASW · UniProt Q12118 · UniProt Q12285
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