MolNFT v1 · #85969 · protein
Crystal structure of VEGFR2 (juxtamembrane and kinase domains) in complex with tivozanib (av-951)
4ASE · Vascular endothelial growth factor receptor 2: “Crystal structure of VEGFR2 (juxtamembrane and kinase domains) in complex with tivozanib (av-951)”. X-ray diffraction, 1 ligand (AV9), 1 pocket (best druggability 0.75). MolNFT v1…
- PDB
- 4ASE
- Type
- protein
- Length
- 305 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vascular endothelial growth factor receptor 2
- EC
- 2.7.10.1
- UniProt
- P35968
- Ligands
- AV9
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vascular endothelial growth factor receptor 2 (EC 2.7.10.1) | protein | 305 | 41% helix, 18% strand | P35968 |
Ligands and binding sites
- AV9 · Tivozanib · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 675 | 0.75 | 0.80 | 72 | AV9 |
Compared structures
- 4ASE · Crystal structure of VEGFR2 (juxtamembrane and kinase domains) in complex with tivozanib… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35968
- Elsewhere: RCSB PDB 4ASE · PDBe 4ASE · UniProt P35968
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