MolNFT v1 · #8589 · protein

Complex of igfbp-5 with igf-I

1H59 · Insulin-like growth factor ia: “Complex of igfbp-5 with igf-I”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #8589 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1H59
Type: protein
Length: 99 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-like growth factor ia; Insulin-like growth factor binding protein 5
UniProt: P01343, P24593
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin-like growth factor ia	protein	54	54% helix, 4% strand	P01343
B	Insulin-like growth factor binding protein 5	protein	45	13% helix, 24% strand	P24593

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.45	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 598 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

1H59 · Complex of IGFBP-5 with IGF-I · the same entry in another collection · chain A against A, TM-score 1.00
P24593 · AlphaFold monomer V2.0 prediction for insulin-like growth factor- binding protein 5… · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01343
Every structure of UniProt P24593
Elsewhere: RCSB PDB 1H59 · PDBe 1H59 · UniProt P01343 · UniProt P24593

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