MolNFT v1 · #85873 · protein
Aip tpr domain in complex with human TOMM20 peptide
4APO · Ah receptor-interacting protein: “Aip tpr domain in complex with human TOMM20 peptide”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.58). MolNFT v1 #85873 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4APO
- Type
- protein
- Length
- 308 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ah receptor-interacting protein; Mitochondrial import receptor subunit TOM20 homolog
- UniProt
- O00170, Q15388
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ah receptor-interacting protein | protein | 142 | 82% helix, 0% strand | O00170 |
| B | Ah receptor-interacting protein | protein | 154 | 84% helix, 0% strand | O00170 |
| D, E | Mitochondrial import receptor subunit TOM20 homolog | protein | 6 | 0% helix, 0% strand | Q15388 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 332 | 0.58 | 0.76 | 38 | 12P |
| 2 | 94 | 0.35 | 0.74 | 20 | empty |
| 3 | 52 | 0.31 | 0.76 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 503 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 499 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 478 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4APO · AIP TPR domain in complex with human Tomm20 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O00170 · AlphaFold monomer V2.0 prediction for ah receptor-interacting protein (O00170) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q15388 · AlphaFold monomer V2.0 prediction for mitochondrial import receptor subunit TOM20 homolog… · a predicted model of the same protein · chain D against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00170
- Every structure of UniProt Q15388
- Elsewhere: RCSB PDB 4APO · PDBe 4APO · UniProt O00170 · UniProt Q15388
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