MolNFT v1 · #85831 · protein

Biomphalaria glabrata acetylcholine-binding protein type 2 (BGACHBP2)

4AOE: “Biomphalaria glabrata acetylcholine-binding protein type 2 (BGACHBP2)”. Electron microscopy, 17 pockets (best druggability 0.76). MolNFT v1 #85831 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4AOE
Type: protein
Length: 1,025 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acetylcholine-binding protein type 2
Pockets: 17 · best druggability 0.76

Structure

electron microscopy · 1 distinct chain · 8% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Acetylcholine-binding protein type 2	protein	205	8% helix, 48% strand	—

Pockets

17 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	321	0.76	0.87	52	empty
2	318	0.75	0.87	50	empty
3	302	0.75	0.87	50	empty
4	316	0.74	0.86	51	empty
5	334	0.73	0.85	53	empty

Interfaces

5 interfaces between chains.

A–B · 1515 Å² buried · 54 hydrogen bonds · protein-protein
A–E · 1512 Å² buried · 54 hydrogen bonds · protein-protein
B–C · 1510 Å² buried · 54 hydrogen bonds · protein-protein
C–D · 1510 Å² buried · 54 hydrogen bonds · protein-protein
D–E · 1502 Å² buried · 54 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

4AOE · Biomphalaria glabrata Acetylcholine-binding protein type 2 (BgAChBP2) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4AOE · PDBe 4AOE

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.