Research workbench
Biomphalaria glabrata acetylcholine-binding protein type 2 (BGACHBP2)
Analyse Biomphalaria glabrata acetylcholine-binding protein type 2 (BGACHBP2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AOE
- Type
- protein
- Length
- 1,025 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetylcholine-binding protein type 2
- Pockets
- 17 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Acetylcholine-binding protein type 2 | protein | 205 | 8% helix, 48% strand | — |
Pockets
17 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 321 | 0.76 | 0.87 | 52 | empty |
| 2 | 318 | 0.75 | 0.87 | 50 | empty |
| 3 | 302 | 0.75 | 0.87 | 50 | empty |
| 4 | 316 | 0.74 | 0.86 | 51 | empty |
| 5 | 334 | 0.73 | 0.85 | 53 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1515 Ų buried · 54 hydrogen bonds · protein-protein
- A–E · 1512 Ų buried · 54 hydrogen bonds · protein-protein
- B–C · 1510 Ų buried · 54 hydrogen bonds · protein-protein
- C–D · 1510 Ų buried · 54 hydrogen bonds · protein-protein
- D–E · 1502 Ų buried · 54 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4AOE · Biomphalaria glabrata Acetylcholine-binding protein type 2 (BgAChBP2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4AOE · PDBe 4AOE
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