MolNFT v1 · #85812 · protein
Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone
4ANP · Phenylalanine-4-hydroxylase: “Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone”. X-ray diffraction, 2 ligands (3QI, FE), 3 pockets (best druggability 0.71). MolNFT v1 #85812 on…
- PDB
- 4ANP
- Type
- protein
- Length
- 309 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine-4-hydroxylase
- EC
- 1.14.16.1
- UniProt
- P00439
- Ligands
- 3QI, FE
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 309 | 48% helix, 13% strand | P00439 |
Ligands and binding sites
- 3QI · 5,6-dimethyl-3-(4-methyl-2-pyridinyl)-2-thioxo-2,3-dihydrothieno[2,3- d]pyrimidin-4(1H)-one · ligand · chains A
- FE · Fe (III) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 534 | 0.71 | 0.80 | 56 | 3QI |
| 2 | 58 | 0.39 | 0.80 | 12 | empty |
| 3 | 53 | 0.25 | 0.73 | 14 | empty |
Compared structures
- 4ANP · Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological… · the same entry in another collection · chain A against A, TM-score 1.00
- P00439 · AlphaFold monomer V2.0 prediction for phenylalanine-4-hydroxylase (P00439) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00439
- Elsewhere: RCSB PDB 4ANP · PDBe 4ANP · UniProt P00439
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