MolNFT v1 · #85761 · protein
C-terminal domain of actin-related protein ARP8 from S. cerevisiae
4AM6 · Actin-like protein ARP8: “C-terminal domain of actin-related protein ARP8 from S. cerevisiae”. X-ray diffraction, 1 ligand (SO4), 16 pockets (best druggability 0.87). MolNFT v1 #85761 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4AM6
- Type
- protein
- Length
- 1,246 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-like protein ARP8
- UniProt
- Q12386
- Ligands
- SO4
- Pockets
- 16 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Actin-like protein ARP8 | protein | 623 | 42% helix, 15% strand | Q12386 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1182 | 0.87 | 0.88 | 128 | SO4 |
| 2 | 1060 | 0.85 | 0.86 | 98 | empty |
| 3 | 677 | 0.81 | 0.85 | 56 | empty |
| 4 | 57 | 0.49 | 0.86 | 15 | empty |
| 5 | 70 | 0.45 | 0.82 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 664 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4AM6 · C-terminal domain of actin-related protein ARP8 from S. cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- Q12386 · AlphaFold monomer V2.0 prediction for actin-like protein ARP8 (Q12386) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12386
- Elsewhere: RCSB PDB 4AM6 · PDBe 4AM6 · UniProt Q12386
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