MolNFT v1 · #85726 · protein + RNA

Crystal structure of the CSY4-minimal crrna complex

4AL7 · CSY4 endoribonuclease: “Crystal structure of the CSY4-minimal crrna complex”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #85726 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4AL7
Type: protein + RNA
Length: 170 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CSY4 endoribonuclease; 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*AP*G)-3'
UniProt: Q02MM2
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CSY4 endoribonuclease	protein	155	19% helix, 30% strand	Q02MM2
B	5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPAP*G)-3'	rna	15	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.31	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 425 Å² buried · 6 hydrogen bonds · protein-nucleic

Compared structures

4AL7 · Crystal structure of the Csy4-minimal crRNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Q02MM2 · AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS6/CSY4 (Q02MM2) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02MM2
Elsewhere: RCSB PDB 4AL7 · PDBe 4AL7 · UniProt Q02MM2

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