MolNFT v1 · #85725 · protein + RNA

Crystal structure of the S148ACSY4-crrna complex

4AL6 · CSY4 endoribonuclease: “Crystal structure of the S148ACSY4-crrna complex”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #85725 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4AL6
Type: protein + RNA
Length: 172 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CSY4 endoribonuclease; Crrna, 5'-R(CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP* CP*AP*GP*C)-3'
UniProt: Q02MM2
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CSY4 endoribonuclease	protein	157	19% helix, 31% strand	Q02MM2
B	Crrna, 5'-R(CPUPGPCPCPGPUPAPUPAPGPGP CPAPGP*C)-3'	rna	15	—	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.40	0.80	18	empty
2	53	0.28	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 408 Å² buried · 5 hydrogen bonds · protein-nucleic

Compared structures

4AL6 · Crystal structure of the S148ACsy4-crRNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Q02MM2 · AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS6/CSY4 (Q02MM2) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02MM2
Elsewhere: RCSB PDB 4AL6 · PDBe 4AL6 · UniProt Q02MM2

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