MolNFT v1 · #8504 · protein
Molecular basis of transmenbrane signalling by sensory rhodopsin II- transducer complex
1H2S: “Molecular basis of transmenbrane signalling by sensory rhodopsin II- transducer complex”. X-ray diffraction, 1 ligand (RET), 3 pockets (best druggability 0.77). MolNFT v1 #8504 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1H2S
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensory rhodopsin II; Sensory rhodopsin II transducer
- UniProt
- P42196, P42259
- Ligands
- RET
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensory rhodopsin II | protein | 225 | 77% helix, 2% strand | P42196 |
| B | Sensory rhodopsin II transducer | protein | 60 | 93% helix, 0% strand | P42259 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.77 | 0.95 | 23 | RET |
| 2 | 126 | 0.60 | 0.85 | 18 | BOG |
| 3 | 198 | 0.52 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 813 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor, 1 covalent (retinal Schiff base, additive adduct).
Compared structures
- 1H2S · Molecular basis of transmenbrane signalling by sensory rhodopsin II-transducer complex · the same entry in another collection · chain A against A, TM-score 1.00
- P42196 · AlphaFold monomer V2.0 prediction for sensory rhodopsin-2 (P42196) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P42259 · AlphaFold monomer V2.0 prediction for sensory rhodopsin II transducer (P42259) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42196
- Every structure of UniProt P42259
- Elsewhere: RCSB PDB 1H2S · PDBe 1H2S · UniProt P42196 · UniProt P42259
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.