MolNFT v1 · #84944 · protein
Crystal structure of the kinase domain of ROR2
3ZZW · Tyrosine-protein kinase transmembrane receptor ROR2: “Crystal structure of the kinase domain of ROR2”. X-ray diffraction, 2 ligands (SO4, CL), 5 pockets (best druggability 0.83). MolNFT v1 #84944 on GenesisL1: 3D structure, binding…
- PDB
- 3ZZW
- Type
- protein
- Length
- 534 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase transmembrane receptor ROR2
- EC
- 2.7.10.1
- UniProt
- Q01974
- Ligands
- SO4, CL
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 269 | 41% helix, 19% strand | Q01974 |
| B | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 265 | 41% helix, 20% strand | Q01974 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.83 | 0.84 | 87 | empty |
| 2 | 131 | 0.68 | 0.89 | 25 | empty |
| 3 | 185 | 0.52 | 0.78 | 23 | empty |
| 4 | 161 | 0.49 | 0.77 | 20 | SO4 |
| 5 | 58 | 0.34 | 0.77 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1413 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3ZZW · Crystal structure of the kinase domain of ROR2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q01974 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase transmembrane receptor ROR2… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01974
- Elsewhere: RCSB PDB 3ZZW · PDBe 3ZZW · UniProt Q01974
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