MolNFT v1 · #84940 · protein
Engineered 12-subunit bacillus stearothermophilus TRP RNA-binding attenuation protein (trap)
3ZZS · Transcription attenuation protein mtrb: “Engineered 12-subunit bacillus stearothermophilus TRP RNA-binding attenuation protein (trap)”. X-ray diffraction, 1 ligand (TRP), 8 pockets (best druggability 0.77). MolNFT v1 #84940 on…
- PDB
- 3ZZS
- Type
- protein
- Length
- 585 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription attenuation protein mtrb
- UniProt
- Q9X6J6
- Ligands
- TRP
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Transcription attenuation protein mtrb | protein | 65 | 0% helix, 62% strand | Q9X6J6 |
Ligands and binding sites
- TRP · Tryptophan · ligand · 9 copies · chains A, B, C, D, E, F, G, H, I
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1085 | 0.77 | 0.79 | 85 | empty |
| 2 | 89 | 0.77 | 0.98 | 21 | TRP |
| 3 | 85 | 0.76 | 0.98 | 22 | TRP |
| 4 | 85 | 0.76 | 0.98 | 20 | TRP |
| 5 | 83 | 0.75 | 0.98 | 21 | TRP |
Interfaces
14 interfaces between chains.
- B–C · 1027 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 1023 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1017 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1009 Ų buried · 13 hydrogen bonds · protein-protein
- H–I · 998 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3ZZS · Engineered 12-subunit Bacillus stearothermophilus trp RNA-binding attenuation protein… · the same entry in another collection · chain I against I, TM-score 1.00
- Q9X6J6 · AlphaFold monomer V2.0 prediction for transcription attenuation protein mtrb (Q9X6J6) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X6J6
- Elsewhere: RCSB PDB 3ZZS · PDBe 3ZZS · UniProt Q9X6J6
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