MolNFT v1 · #84913 · protein

Crystal structure of ribosomal elongation factor (ef)-G from staphylococcus aureus with a fusidic acid hyper-sensitivity mutation M16I

3ZZ0 · Elongation factor G: “Crystal structure of ribosomal elongation factor (ef)-G from staphylococcus aureus with a fusidic acid…”. X-ray diffraction, 17 pockets (best druggability 0.78). MolNFT v1 #84913 on GenesisL1: 3D structure…

PDB: 3ZZ0
Type: protein
Length: 1,296 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongation factor G
UniProt: P68790
Pockets: 17 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Elongation factor G	protein	648	31% helix, 33% strand	P68790

Pockets

17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	983	0.78	0.80	93	empty
2	648	0.74	0.80	70	empty
3	111	0.59	0.85	28	empty
4	129	0.58	0.84	19	empty
5	95	0.57	0.85	18	empty

Interfaces

1 interface between chains.

A–B · 361 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3ZZ0 · Crystal structure of ribosomal elongation factor (EF)-G from Staphylococcus aureus with a… · the same entry in another collection · chain A against A, TM-score 1.00
P68790 · AlphaFold monomer V2.0 prediction for elongation factor G (P68790) · a predicted model of the same protein · chain B against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68790
Elsewhere: RCSB PDB 3ZZ0 · PDBe 3ZZ0 · UniProt P68790

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