Research workbench
Crystal structure of ribosomal elongation factor (ef)-G from staphylococcus aureus with a fusidic acid hyper-sensitivity mutation M16I
Analyse Crystal structure of ribosomal elongation factor (ef)-G from staphylococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZZ0
- Type
- protein
- Length
- 1,296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor G
- UniProt
- P68790
- Pockets
- 17 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Elongation factor G | protein | 648 | 31% helix, 33% strand | P68790 |
Pockets
17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 983 | 0.78 | 0.80 | 93 | empty |
| 2 | 648 | 0.74 | 0.80 | 70 | empty |
| 3 | 111 | 0.59 | 0.85 | 28 | empty |
| 4 | 129 | 0.58 | 0.84 | 19 | empty |
| 5 | 95 | 0.57 | 0.85 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 361 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3ZZ0 · Crystal structure of ribosomal elongation factor (EF)-G from Staphylococcus aureus with a… · the same entry in another collection · chain A against A, TM-score 1.00
- P68790 · AlphaFold monomer V2.0 prediction for elongation factor G (P68790) · a predicted model of the same protein · chain B against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68790
- Elsewhere: RCSB PDB 3ZZ0 · PDBe 3ZZ0 · UniProt P68790
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