MolNFT v1 · #84673 · protein

Crystal structure of human psd-95 PDZ1-2

3ZRT · Disks large homolog 4: “Crystal structure of human psd-95 PDZ1-2”. X-ray diffraction, 9 pockets (best druggability 0.84). MolNFT v1 #84673 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ZRT
Type: protein
Length: 704 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disks large homolog 4
UniProt: P78352
Pockets: 9 · best druggability 0.84

Structure

x-ray diffraction · 4 distinct chains · 14% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disks large homolog 4	protein	197	14% helix, 40% strand	P78352
B	Disks large homolog 4	protein	198	14% helix, 39% strand	P78352
C	Disks large homolog 4	protein	188	15% helix, 41% strand	P78352
D	Disks large homolog 4	protein	121	12% helix, 47% strand	P78352

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	899	0.84	0.86	97	empty
2	152	0.63	0.85	21	empty
3	177	0.62	0.83	30	empty
4	172	0.60	0.83	30	empty
5	110	0.54	0.83	22	empty

Interfaces

3 interfaces between chains.

A–B · 1523 Å² buried · 18 hydrogen bonds · protein-protein
B–D · 1336 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 1284 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3ZRT · Crystal structure of human PSD-95 PDZ1-2 · the same entry in another collection · chain D against D, TM-score 1.00
P78352 · AlphaFold monomer V2.0 prediction for disks large homolog 4 (P78352) · a predicted model of the same protein · chain D against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78352
Elsewhere: RCSB PDB 3ZRT · PDBe 3ZRT · UniProt P78352

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.