MolNFT v1 · #84627 · protein
Structure of tetracycline repressor in complex with antiinducer peptide-TAP1
3ZQF · Tetracycline repressor protein class B from transposon…: “Structure of tetracycline repressor in complex with antiinducer peptide-TAP1”. X-ray diffraction, 3 pockets (best druggability 0.38). MolNFT v1 #84627 on GenesisL1: 3D…
- PDB
- 3ZQF
- Type
- protein
- Length
- 196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetracycline repressor protein class B from transposon TN10, tetracycline repressor…
- UniProt
- P04483, P0ACT4
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetracycline repressor protein class B from transposon TN10, tetracycline repressor protein class D | protein | 183 | 77% helix, 0% strand | P04483, P0ACT4 |
| C | Anti-inducer peptide TAP1 | protein | 13 | 69% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.38 | 0.80 | 14 | empty |
| 2 | 62 | 0.31 | 0.75 | 16 | empty |
| 3 | 50 | 0.29 | 0.75 | 11 | empty |
Interfaces
1 interface between chains.
- A–C · 578 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3ZQF · Structure of Tetracycline repressor in complex with antiinducer peptide-TAP1 · the same entry in another collection · chain A against A, TM-score 1.00
- P04483 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class B from… · a predicted model of the same protein · chain A against A, TM-score 0.94
- P0ACT4 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class D (P0ACT4) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04483
- Every structure of UniProt P0ACT4
- Elsewhere: RCSB PDB 3ZQF · PDBe 3ZQF · UniProt P04483 · UniProt P0ACT4
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