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MolNFT v1 · #84583 · protein + DNA

Crystal structure of the DNA binding ets domain of the human protein fev in complex with DNA

3ZP5: “Crystal structure of the DNA binding ets domain of the human protein fev in complex with DNA”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #84583 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
3ZP5
Type
protein + DNA
Length
112 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Protein fev; 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'…
UniProt
Q99581
Pockets
1 · best druggability 0.37

Structure

x-ray diffraction · 3 distinct chains · 45% helix, 16% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AProtein fevprotein9245% helix, 16% strandQ99581
C5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'dna10——
G5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'dna10——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1530.370.8113empty

Interfaces

3 interfaces between chains.

  • A–C · 587 Ų buried · 8 hydrogen bonds · protein-nucleic
  • C–G · 444 Ų buried · 37 hydrogen bonds · nucleic-nucleic
  • A–G · 440 Ų buried · 9 hydrogen bonds · protein-nucleic

Compared structures

  • 3ZP5 · Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q99581 · AlphaFold monomer V2.0 prediction for protein fev (Q99581) · a predicted model of the same protein · chain A against A, TM-score 0.95

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