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Crystal structure of the DNA binding ets domain of the human protein fev in complex with DNA

Analyse Crystal structure of the DNA binding ets domain of the human protein fev in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3ZP5
Type
protein + DNA
Length
112 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Protein fev; 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'…
UniProt
Q99581
Pockets
1 · best druggability 0.37

Structure

x-ray diffraction · 3 distinct chains · 45% helix, 16% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AProtein fevprotein9245% helix, 16% strandQ99581
C5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'dna10——
G5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'dna10——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1530.370.8113empty

Interfaces

3 interfaces between chains.

  • A–C · 587 Ų buried · 8 hydrogen bonds · protein-nucleic
  • C–G · 444 Ų buried · 37 hydrogen bonds · nucleic-nucleic
  • A–G · 440 Ų buried · 9 hydrogen bonds · protein-nucleic

Compared structures

  • 3ZP5 · Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q99581 · AlphaFold monomer V2.0 prediction for protein fev (Q99581) · a predicted model of the same protein · chain A against A, TM-score 0.95

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