MolNFT v1 · #84523 · protein
Ankyrin repeat and socs-box protein 9 (ASB9) in complex with elonginb and elonginc
3ZNG · Ankyrin repeat and socs box protein 9: “Ankyrin repeat and socs-box protein 9 (ASB9) in complex with elonginb and elonginc”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #84523 on GenesisL1: 3D structure, binding…
- PDB
- 3ZNG
- Type
- protein
- Length
- 860 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ankyrin repeat and socs box protein 9; Transcription elongation factor B polypeptide 1…
- UniProt
- Q96DX5, Q15369, Q15370
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 5 distinct chains · 44% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ankyrin repeat and socs box protein 9 | protein | 258 | 53% helix, 2% strand | Q96DX5 |
| B, E | Transcription elongation factor B polypeptide 1 | protein | 84 | 48% helix, 12% strand | Q15369 |
| C | Transcription elongation factor B polypeptide 2 | protein | 70 | 17% helix, 26% strand | Q15370 |
| D | Ankyrin repeat and socs box protein 9 | protein | 259 | 53% helix, 2% strand | Q96DX5 |
| F | Transcription elongation factor B polypeptide 2 | protein | 105 | 17% helix, 36% strand | Q15370 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 440 | 0.64 | 0.77 | 45 | empty |
| 2 | 402 | 0.61 | 0.77 | 41 | empty |
| 3 | 159 | 0.46 | 0.76 | 17 | empty |
| 4 | 133 | 0.42 | 0.76 | 25 | empty |
| 5 | 108 | 0.37 | 0.74 | 22 | empty |
Interfaces
7 interfaces between chains.
- E–F · 1108 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1043 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 873 Ų buried · 6 hydrogen bonds · protein-protein
- D–E · 853 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 601 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3ZNG · Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC · the same entry in another collection · chain F against F, TM-score 1.00
- Q96DX5 · AlphaFold monomer V2.0 prediction for ankyrin repeat and socs box protein 9 (Q96DX5) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain F against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96DX5
- Every structure of UniProt Q15369
- Every structure of UniProt Q15370
- Elsewhere: RCSB PDB 3ZNG · PDBe 3ZNG · UniProt Q96DX5 · UniProt Q15369 · UniProt Q15370
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