MolNFT v1 · #84372 · protein

Minor-site specific nls (B141)

3ZIR · Importin subunit alpha-2: “Minor-site specific nls (B141)”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #84372 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ZIR
Type: protein
Length: 443 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-2; B141NLS
UniProt: P52293
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-2	protein	426	73% helix, 0% strand	P52293
B	B141NLS	protein	11	36% helix, 0% strand	—
C	B141NLS	protein	6	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.45	0.82	12	empty
2	63	0.31	0.75	11	empty

Interfaces

2 interfaces between chains.

A–B · 839 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 703 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3ZIR · minor-site specific NLS (B141) · the same entry in another collection · chain A against A, TM-score 1.00
P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 3ZIR · PDBe 3ZIR · UniProt P52293

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