MolNFT v1 · #84259 · protein

Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form

3ZFB · Glutathione S-transferase A1: “Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form”. X-ray diffraction, 6 pockets (best druggability 0.81). MolNFT v1 #84259 on GenesisL1: 3D structure…

PDB: 3ZFB
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase A1
EC: 2.5.1.18
UniProt: P08263
Pockets: 6 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 59% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase A1 (EC 2.5.1.18)	protein	208	58% helix, 9% strand	P08263
B	Glutathione S-transferase A1 (EC 2.5.1.18)	protein	206	60% helix, 8% strand	P08263

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1112	0.81	0.82	96	empty
2	106	0.39	0.75	21	empty
3	105	0.37	0.74	20	empty
4	84	0.32	0.74	19	empty
5	58	0.31	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 1535 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

3ZFB · Crystal structure of the I75A mutant of human class alpha glutathione transferase in the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08263
Elsewhere: RCSB PDB 3ZFB · PDBe 3ZFB · UniProt P08263

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